March 27, 2023
Men’s Sexual Wellness
Are you suffering from low libido? Have you taken testosterone and are now realizing your own Testosterone production has decreased and want to stimulate it again? The answer is Enclomiphene. Not to be confused with Clomiphene (aka Clomid), Enclomiphene is the more useful component of Clomiphene.
Enclomiphene is one of the two isomers of clomiphene, which is a mix of zuclomiphene and enclomiphene. Whereas zuclomiphene is more estrogenic, enclomiphene is more anti-estrogenic. Thus, unlike enclomiphene, zuclomiphene, due to activation of the Estrogen Receptor, reduces testosterone levels in men. In conclusion, pure enclomiphene is more favorable than generic clomiphene for the treatment of low testosterone, low libido, and male hypogonadism.
A media release by the FDA for the pharmacy compounding advisory committee compared the efficacy of testosterone replacement therapy against enclomiphene. They wrote that while testosterone replacement therapy often resulted in side effects such as transference risk, supranormal testosterone levels, suppressed spermatogenesis, suppressed testicular function, and testicular atrophy, none of these risks are present in enclomiphene.
In 2009, a study discovered that “short-term clinical safety data for enclomiphene have been satisfactory and equivalent to safety data for testosterone gels and placebo. In 2016, a study on enclomiphene citrate reported that “the ability [of enclomiphene citrate] to treat testosterone deficiency in men while maintaining fertility supports a role for enclomiphene citrate in the treatment of men in whom testosterone therapy is not a suitable option.”
In 2019, a study was published that found that “enclomiphene has been shown to increase testosterone levels while stimulating [follicular-stimulating hormone] and [luteinizing hormone] production.”
The key difference between enclomiphene citrate and traditional testosterone replacement therapy is that enclomiphene citrate stimulates the body to produce its own testosterone, while traditional testosterone replacement therapy replaces low testosterone levels in men with exogenous, synthetic testosterone.
A study conducted in 2013 offered this assessment of the potential of enclomiphene citrate to increase sexual function in men: “If enclomiphene citrate can correct the central defect in men that blocks their ability to produce [lutenizing hormone] and [follicular-stimulating hormone] and thus to produce both testosterone and sperm in the testes, this drug may prove itself superior to other treatments.”
Who should not take Enclomiphene? Patients with brain tumors, patients with a history of liver disease, Patients with uncontrolled adrenal or thyroid dysfunction, and Patients with known allergy to enclomiphene or clomiphene.
Manufacturer’s Certificate of Analysis (COA) for purity verification: pdf