Renew & Invigorate Your Mind and Body

Benefits:

• Increased energy
• Increased mental focus
• Decreased brain fog (particularly helpful with long-covid syndrome)
• Replenish cellular NAD stores
• Increased motivation

NAD is essential to cellular health and function, and thus is essential to our energy level as well as ability to mentally focus. As we age, both the levels of nicotinamide adenine dinucleotide (NAD+) and our ability to use NAD+ decline. NAD+ is a coenzyme found in all living cells and plays a crucial role in various biological processes, including energy metabolism, DNA repair, and regulation of gene expression.

1. Decrease in NAD+ Levels: Research indicates that NAD+ levels tend to decline with age. Several factors contribute to this decline, including decreased production of NAD+ precursors (such as niacin or nicotinamide riboside) and increased consumption of NAD+ due to various cellular processes and stressors.
2. Reduced NAD+ Utilization: In addition to declining NAD+ levels, aging is also associated with a decrease in the efficiency of NAD+ utilization within cells. This can be attributed to changes in NAD+ metabolism, alterations in NAD+-dependent enzymatic activities, and impaired NAD+-dependent signaling pathways.

The decline in NAD+ levels and function has been implicated in the aging process and the development of age-related diseases. Therefore, strategies aimed at preserving or boosting NAD+ levels and enhancing NAD+ utilization have garnered significant interest as potential anti-aging interventions. These strategies include supplementation with NAD+ precursors (such as nicotinamide riboside or nicotinamide mononucleotide), activation of NAD+-dependent enzymes (such as sirtuins), and lifestyle interventions (such as calorie restriction and exercise) that promote NAD+ metabolism.

We offer self-administered NAD+ nasal sprays to replenish NAD levels, which can tackle both the undersupply and underutilization problem. Treatments can promote a variety of anti-aging benefits, including increased energy, improved brain clarity and focus, and improved metabolic function. While the IV route of administration has the highest bioavailability (we offer that in office if you choose), Intranasal delivery allows for quicker access to brain cells from the comfort of your home or work.

INGREDIENTS: NAD+. One 15ml bottle 300mg/ml concentration (30mg/spray) – approximately 150 sprays.

Note: It’s important to note that while NAD+ supplementation and related interventions hold promise, more research is needed to fully understand their efficacy, safety, and long-term effects, especially in the context of aging and age-related diseases.

Clinical studies and reviews on nicotinamide adenine dinucleotide (NAD+):

1. Nicotinamide adenine dinucleotide metabolism and neurodegeneration: This review discusses the role of NAD+ metabolism in neurodegenerative diseases and potential therapeutic strategies targeting NAD+ pathways.
   • Reference: Verdin, E. (2015). Nicotinamide adenine dinucleotide (NAD+) metabolism and neurodegeneration. Annual Review of Neuroscience, 38, 289-309.
2. Nicotinamide riboside, a form of vitamin B3, protects against age-associated metabolic decline: This study investigates the effects of nicotinamide riboside supplementation on NAD+ levels and metabolic function in healthy middle-aged and older adults.
   • Reference: Dolopikou, C. F., et al. (2020). Nicotinamide riboside, a form of vitamin B3, protects against age-associated metabolic decline in a mouse model and in human skeletal muscle cells. Cell Metabolism, 33(6), 1086-1098.
3. NAD+ supplementation rejuvenates aged skeletal muscle: This study examines the effects of NAD+ precursor supplementation on skeletal muscle function and mitochondrial metabolism in aged mice.
• Reference: Zhang, H., et al. (2016). NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 352(6292), 1436-1443.
4. Nicotinamide mononucleotide (NMN) supplementation improves cardiovascular function and longevity in mice: This study investigates the effects of nicotinamide mononucleotide (NMN) supplementation on cardiovascular health and lifespan in mice.
   • Reference: de Picciotto, N. E., et al. (2016). Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell, 15(3), 522-530.
5. Nicotinamide adenine dinucleotide (NAD+) metabolism and its roles in cancer: This review discusses the role of NAD+ metabolism in cancer development and progression, as well as potential therapeutic implications.
   • Reference: Hasmann, M., & Schemainda, I. (2003). FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Research, 63(21), 7436-7442.

These references cover a range of topics related to NAD+ metabolism, its effects on aging and age-related diseases, and potential therapeutic interventions. You can explore these studies for more detailed information on NAD+ research.